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KMID : 0043320150380010026
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Archives of Pharmacal Research
2015 Volume.38 No. 1 p.26 ~ p.34
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Lignans and neolignans from the stems of Vibrunum erosum and their neuroprotective and anti-inflammatory activity
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In Seo-Ji
Seo Kyeong-Hwa
Song Na-Young
Lee Dong-Sung
Kim Youn-Chul
Baek Nam-In
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Abstract
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A new lignan, (7′S,8S,8′S)-3,5′-dimethoxy-3′,4,9′-trihydroxy-7′,9-epoxy-8,8′-lignan, named vibruresinol (1), was isolated from the stems of Viburnum erosum by silica gel, ODS, and Sephadex LH-20 column chromatography. In addition, four other known lignans, (7′R,8S,8′S)-3,5′-dimethoxy-3′,4,8′,9′-tetrahydroxy-7′,9-epoxy-8,8′-lignan (2), (+)-syringaresinol (3), (+)-pinoresinol (4), and (+)-pinoresinol-4-O-β-d-glucopyranoside (5), and five known neolignans, herpetol (6), vibsanol (7), (?)-dehydrodiconiferyl alcohol (8), icariside E4 (9), and dihydrodehydrodiconiferyl alcohol (10), were isolated in the same manner. The chemical structures of the compounds were determined based on spectroscopic data including NMR, MS, and IR. All of the compounds described above were isolated from V. erosum for the first time. The isolated compounds 3, 4, and 6 were evaluated for neuroprotective activity on glutamate-induced cell death in HT22 cells and had EC50 values of 6.33 ± 1.22, 6.96 ± 0.65, and 9.15 ± 0.36 μM, respectively. Likewise, the same compounds had inhibitory activity on NO production in LPS-induced RAW 264.7 cells with IC50 values of 8.30 ± 1.56, 7.89 ± 1.22, and 9.32 ± 0.36 μM, respectively.
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KEYWORD
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Anti-inflammatory, HT22, Neuroprotective activity, RAW 264.7, Vibruresinol, Viburnum erosum
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